Blog

Blog

Feb 2023

Learn More About Polynucleotides

Polynucleotides have emerged as a new concept in the field of regenerative bio stimulation for skin rejuvenation. Extracted from salmon DNA, polynucleotides attach to certain receptors of our cells, initiating a cascade of reactions and attracting stem cells to the tissues that are in need of repair or rejuvenation. This leads to an increase in fibroblast and collagen stimulation, giving immediate hydration and a skin tightening effect. After just two weeks, most of the product will have been absorbed, however there will still be fragments of the product left which continues the bio-stimulation.

Polynucleotides are large molecules that make up nucleic acids such as DNA and RNA.

They are composed of nucleotides, which are the building blocks of these molecules.

Polynucleotides promote skin recovery by increasing angiogenesis (new formation of blood vessels), increasing fibroblasts, growth factors and significantly promoting collagen production. These natural gels are composed of high molecular weight polynucleotide chains that possess several unique features that make them highly viscoelastic and capable of binding and orienting a considerable amount of water molecules in space. The synergistic effect of moisturizing, biostimulating, detoxing against free radicals, and contouring/tightening makes polynucleotide-based gels a promising approach for protecting and rejuvenating the skin. The biostimulating effect of polynucleotides leads to the stimulation of type I collagen production and maturation of fibroblasts. The maturation of fibroblasts and the increased production of collagen determine a strong specific lifting and revitalizing effect suitable for all skin types.

The treatment is injected via a cannula or needles and should be repeated once every 15 or 30 days with 2-4 consecutive treatments in total, depending on what the patient wishes to achieve and needs. The results last 6-12 months, depending on age and lifestyle.

In terms of side effects, bruises and some swelling in the injection area for 1-2 days have been reported, but no other side effects have been reported.

It helps decrease fine lines and wrinkles, working as a powerful skin booster to moisturise, reduce free radical damage and boost collagen production.

In summary, the benefits of polynucleotides for skin rejuvenation are manifold. These natural gels have moisturizing, biostimulating, detoxing, and contouring/tightening effects, making them an exciting approach for protecting and rejuvenating skin. With repeated administration over time, polynucleotides recreate the most favourable physiological conditions for fibroblasts’ regeneration and metabolic activity, resulting in long-lasting biorevitalizing effects.

To find out more about the treatment, click here.

IK H profile pictureIK H
07:30 29 Oct 25
Liesel is professional but friendly and answers all your questions. I would recommend just a consultation, you leave with a wealth of information for you to consider.
Response from the owner 10:25 29 Oct 25
Thank you for such an honest review. We are so happy that you felt so well informed after your consultation, and we hope that this can help to guide you in any treatment choices moving forward.
Michelle Holman profile pictureMichelle Holman
08:13 30 Sep 25
Another visit to Dr Liesel Holler and once again I’m so pleased with the results of my lip filler. The new clinic is lovely and the welcome from reception is great. Highly recommend.
Response from the owner 16:20 18 Dec 23
Thank you Michelle for your great review.. we look forward to seeing you again soon .
Chloe profile pictureChloe
21:31 11 Sep 25
Liesel is amazing! So talented, kind and friendly. I can’t recommend her highly enough!
Response from the owner 10:39 12 Sep 25
Thank you Chloe for this great review. We look forward to seeing you again soon ,at our Chislehurst clinic.
Kerry Hambly profile pictureKerry Hambly
14:29 20 Aug 25
Liesel always takes time making one feel special
She hears what you want to achieve.
Most of all Liesel never hard sells she will not do a procedure if she doesn’t think you will achieve miracles
Response from the owner 15:54 19 Nov 21
Thank you Kerry
Samantha Arnold profile pictureSamantha Arnold
07:19 13 Aug 25
Not one bruise. Lots of discussion on what would be the best option, and all my concerns were listened to and acted upon. Couldn't be happier with the results.
Response from the owner 07:53 18 Aug 25
Thank you for this wonderful review. We are so pleased that you are happy with your experience at our Chislehurst clinic and we look forward to seeing you again.
Virginia Mc dowell profile pictureVirginia Mc dowell
17:17 06 Aug 25
I can’t recommend dr liesel holler enough! She is so caring and professional in he work! She takes a lot of time to really get to know her clients so she can give the best results! I have just had some treatments with her! I am delighted with the result 💇‍♀️❤️
Response from the owner 14:44 07 Jan 21
Thank you Gin! x
priya ilangovan profile picturepriya ilangovan
15:05 20 Jul 25
I had my first and recent Hydra facial here. Agni, was fantastic, friendly, patient and professional throughout the session. I had a very relaxing time and came back home with a healthy facial glow. I would go there again soon for sure for my second session 🤗!
Response from the owner 08:47 21 Jul 25
Thank you Priya for this glowing review. We are thrilled you were so happy with your experience and look forward to welcoming you back to our Chislehurst clinic.
emily profile pictureemily
09:15 12 Jun 25
Dr Liesel Holler is incredibly knowledgable and approachable and I feel I'm in really good hands under her care! She listened to my concerns intently and advised as to the safest way forward.
Response from the owner 09:36 12 Jun 25
Thank you Emily for this review. We are so happy that you feel good under the care of our clinic and Dr Liesel and we look forward to welcoming you back to our Chislehurst clinic in the future.
Ursula Venus profile pictureUrsula Venus
05:58 06 Jun 25
Amazing service from both Shara and Dr Liesel. Very professional
Response from the owner 06:22 06 Jun 25
Thank you so much Ursula for this lovely review. We look forward to seeing you again at our new Chislehurst clinic.
stacey Harwood profile picturestacey Harwood
10:51 24 May 23
Firstly, this is a friendly and welcoming clinic.

Dr Liesel is not only extremely knowledgeable; she also has a genuine care for her patients. She takes the time to listen and what I like best is her approach - less is more! I never feel pushed into anything and she fully explains the procedure and after care. I know I am in safe hands.

A loyal client who is very lucky to find an aesthetic doctor who is professional, smart and caring. Thank you Dr Liesel.
Apples1974 profile pictureApples1974
11:04 26 Apr 23
Dr Holler has a wealth of experience and knowledge that is invaluable. I was nervous ahead of my treatment, but I was immediately put at ease. My procedure was talked through with me thoroughly and Dr Holler took the time to suggest some alternatives that would better suit me. I would absolutely recommend Dr Holler. I couldn't be happier with my results.
Lauren profile pictureLauren
15:26 28 Mar 23
Dr Liesel has a wonderful calming presence about her. You can tell she genuinely cares about each of her patients and will never rush a treatment or go overboard. She takes time to listen to your concerns but is never pushy. She is such a professional and I would recommend her to anyone ☺️
Alexandra Taylor profile pictureAlexandra Taylor
13:41 24 Feb 23
This is my second treatment with Dr Liesel Holler and each time she has discussed and explained things in detail with me and carefully assessed my facial profile.

My results are very natural and exactly as I wanted. It’s clear she is very skilled and knowledgeable and treats each patient uniquely. I can be quite nervous and I feel totally at ease with Dr Liesel Holler and she is the most gentle with a needle that I’ve ever experienced.

I wouldn’t trust anyone else with my face now. Thank you again!